Functional Monitoring of Small Bowel Motility: Comparison of Spasmolysis Induced by Glucagon or Buscopan
نویسندگان
چکیده
Purpose: Peristalsis of the small bowel leads to considerable movement artifacts in MR-examinations, which hamper diagnostic quality [1, 2]. Therefore a spasmolytic premedication agent is commonly administered intravenously to inhibit bowel motion, shortly before performing the abdominal imaging studies. Two main paralyzing agents, hyoscine N-butylbromide (HBB; Buscopan Boehringer Ingelheim, Germany) and glucagon (GlucaGen, Novo Nordisk, Küsnacht, Switzerland) are used in clinical routine to minimize bowel motion. Little has been reported about their pharmacological profile for inhibiting bowel wall motion in cross-sectional imaging. The aim of this prospective clinical volunteer MRI study was to characterize and compare intraindividually the spasmolytic effect on small bowel motility of 40 mg hyoscine HBB vs. 1 mg glucagon both administered intravenously over a time period of 60 minutes.
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